Common Terminology Criteria for Adverse Events

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The NCI Common Terminology Criteria for Adverse Events is a descriptive terminology which can be utilized for Adverse Event (AE) reporting.

A grading (severity) scale is provided for each AE term (1 to 5). A single dash (-) indicates a Grade is not available. Not all Grades are appropriate for all AEs. Therefore, some AEs are listed with fewer than five options for Grade selection.

A brief Definition is provided to clarify the meaning of each AE term. A single dash (-) indicates a Definition is not available.


An Adverse Event (AE) is any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medical treatment or procedure that may or may not be considered related to the medical treatment or procedure.

An AE is a term that is a unique representation of a specific event used for medical documentation and scientific analyses.


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